can collagen peptides cause migraines

Its always best to speak with your doctor when beginning to take new supplements, particularly in order to avoid adverse interactions with medications. Learn more. Effects of protein supplements on muscle damage, soreness and recovery of muscle function and physical performance: a systematic review. Health Benefits of Collagen: Pros and Cons, Nutrition, and More Whether or not collagen supplements are effective depends on what a person uses collagen for. View abstract. There are several potential health benefits that collagen supplements offer. Undergoing the hydrolyzation process makes collagen easier for the body to absorb. Before Also, in many cases, the collagen is hydrolyzed. That being said, we want to point out that these side effects are not common. However, it is important to understand what collagen and biotin are and what research is available to support these claims. Print 2018 Dec 21. Prowting JL, Bemben D, Black CD, Day EA, Campbell JA. Collagen supplements have the potential to cause both headaches and migraines., According to a few case studies on using collagen to treat osteoarthritis, when participants were using the collagen supplement, they did report a lower pain level in their joints but among the most commonly reported side effects was a headache from time to time.. This information may not fit your specific health circumstances. As well, since the FDA considers collagen a dietary supplement, the safety and effectiveness of collagen peptide supplements are also unregulated. These symptoms are usually mild and resolve on their own. It's possible to be sensitive or allergic to certain collagen Scientists describe collagenous colitis as a type of microscopic colitis because the inflammation it causes is only noticeable under a microscope. 2000;30(2):87-99. Clifford T, Ventress M, Allerton DM, et al. Kalman DS, Schwartz HI, Pachon J, Sheldon E, Almada AL. Praet SFE, Purdam CR, Welvaert M, et al. Nutrients. The effects of beetroot juice supplementation on indices of muscle damage following eccentric exercise. This Using a Trc T, Bohmov J. Efficacy and tolerance of enzymatic hydrolysed collagen (EHC) vs. glucosamine sulphate (GS) in the treatment of knee osteoarthritis (KOA). Effect of Oral Ingestion of Low-Molecular Collagen Peptides Derived from Skate (Raja Kenojei) Skin on Body Fat in Overweight Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. sharing sensitive information, make sure youre on a federal The .gov means its official. Sangsuwan W, Asawanonda P. Four-weeks daily intake of oral collagen hydrolysate results in improved skin elasticity, especially in sun-exposed areas: a randomized, double-blind, placebo-controlled trial. Given that glutamic acid is one of the amino acids present in the collagen protein, eating too many collagen peptides may indirectly lead to an unwanted headache. Collagen supplements Most collagen supplements are not vegan or vegetarian friendly. pii: E892. Theres currently 80 approved peptide drugs worldwide. A randomized controlled trial on the efficacy and safety of a food ingredient, collagen hydrolysate, for improving joint comfort. Siahaan EA, Agusman, Pangestuti R, Shin KH, Kim SK. Int J Tissue React. Additionally, collagen contains various animal proteins, which can cause allergic reactions in some people. J Neuroimmune Pharmacol. Both effects persisted after 12 weeks. Cochrane Database Syst Rev. WebCollagen is so big and challenging that we cant absorb it as is when we consume it. MeSH Liquid collagen: Benefits and risks for hair, skin, and more Therapeutic role of melatonin in migraine prophylaxis: A systematic review. Zdzieblik D, Oesser S, Baumstark MW, Gollhofer A, Knig D. Collagen peptide supplementation in combination with resistance training improves body composition and increases muscle strength in elderly sarcopenic men: a randomised controlled trial. 2015;18(3):324-31. 2015;14(3):30-8. 2017;42(6):588-595. It is made up of amino acids which build our skin, connective tissue, organs, and bones and plays a role in forming the fibroblasts (cell clusters) which allow new cells to grow and replace dead ones. WebGlutamate is implicated in cortical spreading depression, trigeminovascular activation, and central sensitization. 2020;12(3):618.View abstract. Collagen supplementation as a complementary therapy for the prevention and treatment of osteoporosis and osteoarthritis: A systematic review. Lpez-Martnez MI, Miguel M, Garcs-Rimn M. Front Nutr. Int J Environ Res Public Health 2021;18(9):4837. A wide range of dietary supplements is offered to improve skin health. Lee SK, Posthauer ME, Dorner B, Redovian V, Maloney MJ. An official website of the United States government. Federal government websites often end in .gov or .mil. Conclusion: Bookshelf Maia Campos PMBG, Franco RSB, Kakuda L, Cadioli GF, Costa GMD, Bouvret E. Oral Supplementation with Hydrolyzed Fish Cartilage Improves the Morphological and Structural Characteristics of the Skin: A Double-Blind, Placebo-Controlled Clinical Study. 2018 Dec 28;7(1):5. doi: 10.3390/sports7010005. In conclusion, CP had moderate benefits for the recovery of CMJ and muscle soreness but had no influence on inflammation and bone collagen synthesis. Are they safe, and do they work? Skin rashes. Collagen Peptides: What They Can and Can't Do for Real - Greatist As mentioned, collagen is a large protein that contains many different peptides and amino acids. View abstract. Glutamate is implicated in cortical spreading depression, trigeminovascular activation, and central sensitization. Collagen Peptides Epub 2015 Nov 4. This can lead to the development of conditions such as osteoporosis. Nutrients. Using a double-blind, independent group's design, 24 recreationally active males consumed either 20 g day-1 of CP or a placebo control (CON) for 7 days before and 2 days after performing 150 drop jumps. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. Be the first to hear about exclusive offers and latest arrivals. WebYes, collagen does make you poop more! J Cosmet Dermatol. We include products we think are useful for our readers. The Bone Biomarker Response to an Acute Bout of Exercise: A Systematic Review with Meta-Analysis. 2018 Mar;78(4):411-437. doi: 10.1007/s40265-018-0865-y. 2004;26(3-4):105-11. View abstract. Collagen is a protein that promotes skin elasticity. FASEB Experimental Biology 2004 Abstracts, Washington DC, April 17-21, 2004; A90. 2019;29(5):526-531. Similar to vegan options, a person may want to look for a collagen supplement that specifically aims to support the keto diet. Aczl T, Benczik B, gg B, Krtsi T, Urbn P, Bauer W, Gyenesei A, Tuka B, Tajti J, Ferdinandy P, Vcsei L, Blcskei K, Kun J, Helyes Z. J Headache Pain. View abstract. Oxid Med Cell Longev. pii: E157. 2018;13(4):438-52. doi: 10.1002/brb3.2820. Insulin is an example of a peptide drug, which is composed of 51 amino acids. Collagen Peptides: The Benefits & How To Pick A Supplement Additionally, some people may be allergic to collagen or have an intolerance to it. Effects of collagen peptides on recovery following eccentric exercise in resistance-trained males-A pilot study. Certain foods contain nutrients that are necessary for collagen production. 2010;35(6):797-804. J Bone Metab 2021;28(3):207-213. We currently have no information for COLLAGEN PEPTIDES overview. Benefits of sunlight: a bright spot for human health. If you take too much collagen, it can throw off the balance of amino acids in your body and lead to side effects such as headaches, digestive issues, and fatigue. Although certain foods, such as bone broth, contain collagen, people who want wrinkle-free skin or other health benefits often look to supplements to increase their collagen intake. 2022 Sep 2;23(1):113. doi: 10.1186/s10194-022-01478-w. Medicine (Baltimore). Collagen peptides powder may also cause headaches, dizziness, or lightheadedness in some users. Semin Arthritis Rheum. A person can also use collagen supplements while following a keto diet plan. View abstract. View abstract. View abstract. Bagheri Miyab K, Alipoor E, Vaghardoost R, et al. Effects of hydrolyzed collagen supplementation on skin aging: a systematic review and meta-analysis. An official website of the United States government. View abstract. View abstract. Evans M, Lewis ED, Zakaria N, Pelipyagina T, Guthrie N. A randomized, triple-blind, placebo-controlled, parallel study to evaluate the efficacy of a freshwater marine collagen on skin wrinkles and elasticity. View abstract. Learn about some top options here. View abstract. For most people, taking collagen should not have any major effects or health consequences. Porfrio, E. & Fanaro, G. B. We do not provide medical diagnosis, advice, or treatments. Having, high levels of calcium in your blood is also known as hypercalcemia, and seems to be more predominantly an issue in women., Whether collagen can cause headaches or not is a great question to be asking, especially when trying to decide which supplements are right for you and your body. J Cosmet Dermatol. Unauthorized use of these marks is strictly prohibited. Would you like email updates of new search results? Int Orthop. Unable to load your collection due to an error, Unable to load your delegates due to an error. Zmitek K, Zmitek J, Rogl Butina M, Pogacnik T. Effects of a combination of water-soluble coenzyme Q10 and collagen on skin parameters and condition: Results of a randomised, placebo-controlled, double-blind study. Rheumatoid arthritis, lupus, dermatomyositis and scleroderma are autoimmune, connective tissue diseases known to damage collagen. Whether used as a powder in smoothies or as oral supplements, collagen has all the rage nowadays. Can poor sleep impact your weight loss goals? Complement Ther Med. This group saw a significant reduction in artery stiffness and a reduction in their low-density lipoprotein, or bad, cholesterol levels. Kim DU, Chung HC, Choi J, Sakai Y, Lee BY. Hexsel D, Zague V, Schunck M, Siega C, Camozzato FO, Oesser S. Oral supplementation with specific bioactive collagen peptides improves nail growth and reduces symptoms of brittle nails. Please enable it to take advantage of the complete set of features! Inoue N, Sugihara F, Wang X. Ingestion of bioactive collagen hydrolysates enhance facial skin moisture and elasticity and reduce facial ageing signs in a randomised double-blind placebo-controlled clinical study. Appl Physiol Nutr Metab. Chemical additives in collagen peptide supplements, such as anti-caking substances and preservatives are common causes of acne flare-ups in those who notice increased breakouts with collagen use. 8600 Rockville Pike Select a condition to view a list of vitamins. Protein and Sport: Alternative Sources and Strategies for Bioactive and Sustainable Sports Nutrition. Prokopov A, Pavlackov J, Mokrejs P, Gl R. Collagen Hydrolysate Prepared from Chicken By-Product as a Functional Polymer in Cosmetic Formulation. Collagen vs. biotin for the skin and hair, What to know about L-tryptophan supplements, The best collagen supplements: How to choose, a general feeling of heaviness in the stomach. HHS Vulnerability Disclosure, Help "The riskiest side effects of any treatment are usually allergic 2010;340(5):360-6. CNS Neurol Disord Drug Targets. A 2016 animal study also found that collagen hydrolysate (also called collagen peptides) reduced fat cell size and weight gain in rats. Marine Collagen sharing sensitive information, make sure youre on a federal Still, the only real risk with collagen is knowing the source, quality, and reliability of the supplement company., It is important to get to know the company you are buying a supplement from and to ensure that they are transparent about all of their ingredients and product sourcing., If the company is not transparent, and you have no idea what is in the supplement, there is a higher chance the collagen can cause headaches and other issues., Beyond the product itself and ingredients, dosage can also impact how safe it is to use collagen as a daily supplement., As with anything, it is possible to take too much and have an adverse reaction. SkinnyFit Super Youth Side Effects Czajka A, Kania EM, Genovese L, et al. This in turn, can lead to a number of side effects, including abnormal heart rhythms. These side effects manifest as clinical symptoms best identified by a medical professional. Rahimi MD, Hassani P, Kheirkhah MT, Fadardi JS. Does Collagen Make You Poop More? ANSWERED Bethesda, MD 20894, Web Policies So, these additional things are more often associated with certain side effects like an upset stomach. Cureus. J Sci Food Agric. 2012;7:267-273. 2017 Dec 14;12(12):CD009789. Yes. Taking collagen supplements may also help support a healthy cardiovascular system. Asserin J, Lati E, Shioya T, Prawitt J. Type 2: This is present primarily in cartilage and can help promote joint health. Choi SY, Kim WG, Ko EJ, et al. Journal of Cosmetic Dermatology Published by Wiley Periodicals, Inc. Reumatismo. Expert Opin Investig Drugs. Its important, in such cases, not to over-consume collagen peptides or take them right before sleeping. A pilot study for the detection of cyclic prolyl-hydroxyproline (Pro-Hyp) in human blood after ingestion of collagen hydrolysate. Burns. Jacob Y, Anderton RS, Cochrane Wilkie JL, Rogalski B, Laws SM, Jones A, Spiteri T, Hince D, Hart NH. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Side effects vary depending on which type of collagen supplement you take, but they are generally minor overall. Alcock RD, Shaw GC, Tee N, Welvaert M, Burke LM. Your Collagen Supplement Causing Headaches Prowting JL, Bemben D, Black CD, Day EA, Campbell JA. View abstract. J Dermatol Sci. Peptides pii: E1356. 4 Best Ones and Alternatives, Probiotics for Acne: Do They Work, How to Use Them and More, Try a preventative approach. Side Effects of Collagen Peptides on the Skin, Anti-Aging Alternatives to Collagen Peptides Supplements, Vitamin C for Acne Scars: Efficacy, How It Works, Before and Afters, Everything You Need To Know About Icon Laser by Cynosure, Vitamin C Serum for Acne: Benefits, How to Choose One, and How to Use It, Everything You Need To Know About PicoSure Laser by Cynosure, Vitamins for Acne: Do They Work? Conclusions and Relevance: Preliminary results are promising for the short and long-term use of oral collagen supplements for wound healing and skin aging. Effect of the novel low molecular weight hydrolyzed chicken sternal cartilage extract, BioCell Collagen, on improving osteoarthritis-related symptoms: a randomized, double-blind, placebo-controlled trial. (2016). While we have no reports of ProT Gold users experiencing headaches or migraines after using our collagen products, preliminary research into the topic suggests that there may be a correlation between some collagen supplements and headaches., Whether collagen can cause headaches or not often is dependent on the person taking the supplement, the dosage, the type of collagen, and the supplement quality itself., If you suspect that your supplemental collagen can cause headaches or migraines, then exploring why you have this reaction and how to prevent it will be the first place to start., Before we get into whether collagen can cause headaches, lets look at the overall safety of collagen supplements in general., If youre asking the question: can collagen cause headaches? You are probably also interested in other possible side effects of collagen, and if collagen is a safe supplement to take., Its hard to answer whether collagen can cause headaches and if the supplement itself is safe, simply because the FDA does not regulate most supplements., Since there is such limited regulation of supplements on the market, this leads to immense skepticism regarding how safe they really are and what side effects they cause., The lack of regulation when it comes to supplements versus drugs means that not all supplement companies necessarily have to prove their claims., So, if they are simply trying to sell a product to the consumer, they do not have to have evidence to support whether or not the collagen supplement they are providing actually will benefit the consumer, or whether their supplemental collagen can cause headaches or other issues., Still, the FDA does recognize ingestible collagen as Generally Recognized As Safe (GRAS)., There have been specific collagen supplements that have been recalled by the FDA for safety reasons, which is why it is important to buy from a reputable brand., For instance, our liquid collagen supplement, ProT Gold, is actually recognized as a medical food, which is why it has a nutritional label, not a supplement label., Because of this, ProT Gold is also trusted by over 3,000 medical facilities and used widely for medical nutrition therapy., Something that should be recognized about collagen as a supplement is that it is natural. migraine 2012 Jun;20(3):124-30. Before 2015;95(4):702-7. Oral Intake of Enzymatically Decomposed AP Collagen Peptides Improves Skin Moisture and Ceramide and Natural Moisturizing Factor Contents in the Stratum Corneum. Another similar study in the journal Skin Pharmacology and Physiology looked at the effects of collagen supplements on womens skin. A controlled trial to determine the efficacy of red and near-infrared light treatment in patient satisfaction, reduction of fine lines, wrinkles, skin roughness, and intradermal collagen density increase. 2014;27(3):113-9. doi: 10.1159/000355523. These preclinical and clinical observations argue for a strong link between migraine and the glutamatergic system, a link that is important to further characterize in an effort to better understand migraine mechanisms and deliver effective therapies. Unable to load your collection due to an error, Unable to load your delegates due to an error. WebOne small study found that men who took collagen peptide supplements during a 12-week strength training program saw more increases in muscle mass and strength than those Collagen peptide supplements usually come in the form of either powders or pills and are generally considered equally safe and effective for skin care purposes. View abstract. 8600 Rockville Pike When choosing your collagen peptides supplement, be sure its manufacturer hasnt been called out by the FDA. All rights reserved. Be sure to choose a collagen peptide product that best suits your needs and goals. View abstract. 2016;39(3):428-34. View abstract. Arch Acad Emerg Med 2021;9(1):e50. View abstract. J Sci Food Agric. This site needs JavaScript to work properly. Maia Campos PMBG, Melo MO, Siqueira Csar FC. J Cosmet Dermatol. Saiga-Egusa A, Iwai K, Hayakawa T, Takahata Y, Morimatsu F. Antihypertensive effects and endothelial progenitor cell activation by intake of chicken collagen hydrolysate in pre- and mild-hypertension. Hakuta A, Yamaguchi Y, Okawa T, Yamamoto S, Sakai Y, Aihara M. Anti-inflammatory effect of collagen tripeptide in atopic dermatitis. What is the latest research on the form of cancer Jimmy Carter has? Nutrients. However, it is important to understand what collagen and biotin are and what research is available to support these claims. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Subscribe to get special offers, free giveaways, and once-in-a-lifetime deals. and transmitted securely. Some collage supplements do source from these animals, so when taking them, youre likely to have an allergic reaction of some kind., The question of whether collagen can cause headaches or not is somewhat subjective, but the short answer is yes. Int J Sport Nutr Exerc Metab 2021. It is good to know that collagen can cause headaches for some users, but how can collagen cause headaches? Methods: 2020;7:580918. As with any supplement, collagen supplements do have some potential side effects, especially when taken in excess. Int J Dermatol 2021;60(12):1449-1461. However, the likelihood of a headache due to collagen may be minimal in comparison to the many benefits of collagen., When looking for a collagen supplement, check the ingredient label and see what the absorption rate is. Collagen is concentrated in bones, ligaments, tendons, skin, blood Collagen View abstract. Mood alteration: If you already have any type of mood disorder or imbalance in serotonin, collagen may impact how you feel. Read on to learn more about L-tryptophan, including its safety and efficacy. Can Collagen Cause High Triglycerides. Maia Campos PMBG, Melo MO, Siqueira Csar FC. View abstract. View abstract. Type 1: This is one of the most abundant types present in the human body and helps support healthy skin. Proksch E, Schunck M, Zague V, Segger D, Degwert J, Oesser S. Skin Pharmacol Physiol. Antioxidants for preventing and reducing muscle soreness after exercise. To protect collagen stores, doctors recommend you use a broad-spectrum sunscreen with an SPF of 30 or higher every day, refrain from, Topical creams which include retinoic acid or, Despite the well-known risks of exposure to. Collagen Peptides for Hair. Clin Exp Dermatol. Wauquier F, Boutin-Wittrant L, Bouvret E, Le Faouder J, Roux V, Macian N, Pickering G, Wittrant Y. Nutrients. It's rich in amino acids that play an important role in the building of joint cartilage and it may have anti Collagen supplements can help improve skin health. National Library of Medicine If you buy through links on this page, we may earn a small commission Heres our process. Please enable it to take advantage of the complete set of features! One thing that you can look for is a medical grade collagen supplement like ProT Gold., It is still a possibility that you may experience some side effects with any collagen supplement. As a person ages, their joints start to break down. If you take more collagen than your body can digest, it will cause problems adapting the body to new levels of energy. Others may experience constipation when they begin to integrate collagen peptides into their supplement regime, while others notice a reduction in appetite. Unauthorized use of these marks is strictly prohibited. Hydroxyproline ingestion and urinary oxalate and glycolate excretion. View abstract. The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials. Bone mineral density is key to preventing bone fractures. For example, in a study in the Journal of Medical Nutrition and Nutraceuticals, several women drank a mixture containing various vitamins, minerals, hydrolyzed collagen, and hyaluronic acid. PMC These include: Collagen peptide supplements can offer a range of benefits from improved skin health to a reduction in joint pain and stronger hair and nails. Many believe that collagen supplements can help reduce the effects of aging, such as by adding moisture to the skin, reducing wrinkles, and improving elasticity. Beneficial Effects of Oral Supplementation With Ovoderm on Human Skin Physiology: Two Pilot Studies. Heart failure: Could a low sodium diet sometimes do more harm than good? doi: 10.7759/cureus.27666. Lim, S. H., Sun, Y., Thiruvallur Madanagopal, T., Rosa, V., & Kang, L. (2018). Specific Collagen Peptides Improve Bone Mineral Density and Bone Markers in Postmenopausal Women-A Randomized Controlled Study. Mar Drugs. Skin Pharmacol Physiol. Wunsch, A., & Matuschka, K. (2014). Mar Drugs. There are numerous reasons why you might be taking a collagen supplement. Collagen and biotin may both help promote skin and hair health, but each has different pros and cons. What are L-tryptophan supplements? They accomplish this by stimulating new collagen growth, in turn reducing wrinkles, boosting skin elasticity, and improving skin hydration. Apweiler E, Wallace D, Stansfield S, Allerton DM, Brown MA, Stevenson EJ, Clifford T. Sports (Basel). 2021 Jan 1;31(1):32-39. doi: 10.1123/ijsnem.2020-0149. View abstract. pii: E76. Collagen Collagen benefits for skin and hair.*. Enhanced Skin Permeation of Anti-wrinkle Peptides via Molecular Modification. Sci Rep. 2022 Jun 13;12(1):9804. doi: 10.1038/s41598-022-14068-2. collagen supplements Maturitas. Accessibility Collagen loss with age can cause increased tooth sensitivity and decreased tooth strength. Background: -CTX and P1NP were unaffected by CP supplementation (P > 0.05). Lampropoulou-Adamidou K, Karlafti E, Argyrou C, et al. Oral intake of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis. 2011;35(3):341-8. Would you like email updates of new search results? Cannabis Addiction and the Brain: a Review. CMJ height recovered quicker with CP than CON at 48 h (P = 0.050; CP 89.96 12.85 vs. CON 78.67 14.41% of baseline values; ES = 0.55). Dietary supplements do not improve bone morphology or mechanical properties in young female C57BL/6 mice. In particular, the spongy cartilage of the joints starts to wear away. The protein collagen has 3 essential amino acids that decrease constipation, helps with leaky gut syndrome, and even reduces diarrhea. The site is secure. 2015;14(4):291-301. Some other known benefits of collagen peptides include: Consuming collagen peptides are good for you insofar as they may offer a variety of health benefits, from improving joint health to improving your skin. Collagen is a protein that our body already produces, so when taking it in a supplement form, you are replenishing your collagen stores with animal-based collagen., Since it is something that your body already recognizes and needs, the risk is relatively minimal and there are few health concerns about how collagen reacts within your body., Now, this isnt to say that there are no side effects, allergy concerns, or risks involved in taking a collagen supplement., Introducing any new supplement into your diet should be done so with the consultation of a medical professional, especially if you are taking prescription medications, are pregnant, or have any underlying health conditions., Every person taking a supplement may have a different reaction when introducing it into their diet. Peptides We avoid using tertiary references. A calcium-collagen chelate dietary supplement attenuates bone loss in postmenopausal women with osteopenia: a randomized controlled trial. View abstract. However, such claims do not yet have scientific evidence to support them. One amino acid in particular, glutamic acid Role of collagen hydrolysate in bone and joint disease.Semin Arthritis Rheum 2000;30:87-99. Although rare and typically mild, side effects of collagen peptides on skin often take the form of inflammation and skin breakouts or rashes. Is the ketogenic diet right for autoimmune conditions? Can ANSWER: Collagen and biotin supplements appear to be getting attention in the media for promoting healthy aging, along with joint and bone health. Can Collagen Supplements Cause High Cholesterol The source of the collagen itself should also be a consideration, primarily for those that have a fish or shellfish allergy of any kind. J Clin Densitom 2021. Collagen Peptides The participants engaged in regular exercise for 12 weeks. Pressure ulcer healing with a concentrated, fortified, collagen protein hydrolysate supplement: a randomized controlled trial. Information from this source is evidence-based and objective, and without commercial influence. Part of this simply has to do with your individual body and the interactions it has with certain ingredients and substances., How much collagen you take, when you take it, and the combination of other genetic factors or medications you take can also influence the severity of the side effects you may experience when taking a collagen supplement., Through general anecdotal evidence, it does seem like collagen users often struggle with side effects, like headaches or bloating, when taking collagen supplements on a daily basis and when taking collagen in the whole form (i.e., bone broth)., Some of the most commonly reportedcollagen side effects may include:.